Program
15.00 - 18.00
Registration
18.00 - 18.15
Welcome
Unstirred layers, baseball gloves, electrostatics, and molten globules: Lessons learned from 50 years of hemoglobin research
18.15 - 19.00
Opening Session
19.00 - 21.00
Welcome Reception
9.00 - 12.30
Paolo Ascenzi
Thomas Hankeln
Norifumi Kawada
Thomas Hankeln
Norifumi Kawada
Session 1: Globins in Health and Disease
9.00 - 9.30
The role of cytoglobin in regulating blood pressure and vascular tone
9.30 - 10.00
Antagonistic regulation of CYGB expression in human hepatic stellate cells by FGF2 and TGF-b1
10.00 - 10.15
Neural stem cells as a tool to study the effect of Ngb-deficiency in neurodevelopment
10.30 - 11.00
Coffee-break
11.00 - 11.30
High neuroglobin levels impact on mitochondrial dynamics in neuron derived cells
11.30 - 12.00
Genetic ablation of androglobin reveals multiple phenotypes
12.00 - 12.15
Hemoglobin as participant of programmable hemolysis, and protective role of dinitrosyl iron complexes
12.15 - 12.30
Isolation of recombinant human hemoglobin variants using molecularly imprinted polymers
12.30 - 14.30
Lunch
Poster session
14.30 - 17.45
Victor Guallar
Markus Meuwly
Giulietta Smulevich
Markus Meuwly
Giulietta Smulevich
Session 2: Structure, Function, and Dynamics
14.30 - 15.00
Heme-ligand interactions in the bacterial CO sensor protein RcoM-2
15.00 - 15.30
Oxygen binding and allosterism in human hemoglobin studied with multiscale computer simulations
15.30 - 15.45
Globin-based biosensors using mesoporous materials
15.45 - 16.00
Snapshot of an Oxygen Intermediate in the Catalytic Reaction of Cytochrome c Oxidase
16.00 - 16.30
Coffee - break
16.30 - 17.00
Resonance Raman spectroscopy and molecular dynamics simulations: A working marriage to investigate the structure -function relationships
17.00 - 17.30
Action mechanisms of inhibitors targeting human indoleamine 2,3-dioxygenase 1 and tryptophan dioxygenase
17.30 - 17.45
Fingerprinting the free radicals in globins, haem peroxidases and not only – tyrosine and tryptophan radicals EPR spectra simulation
18:00
Discussion about O2BIP 2020
10.15 - 10.30
Hemoglobin is conformationally gated to synergize O2 and NO binding to match O2 delivery with metabolic demand
17:45 - 18:00
The heme-iron coordination state and its role in the channel formation of a membrane-bound globin coupled sensor
9.00 - 12.30
Kanak Dikshit
Martino Bolognesi
Martino Bolognesi
Session 3: Non Vertebrate, Bacterial, and Plants Oxygen Binding Proteins
9.00 - 9.30
A diversity of globins in non-vertebrate, bacteria and plants: An overview
9.30 - 10.00
Legume hemoglobins: Roles inside and outside the symbiosis
10.00 - 10.15
Distal ligand selection in hexacoordinate cyanobacterial and algal hemoglobins Synechocystis trHbs
10.15 - 10.30
New insight into mycobacterial CO responses
10.30 - 11.00
Coffee - break
11.00 - 11.30
Oxygen sensing by a Mycobacterium tuberculosis system with one target DevR, for two sensor kinases, DevS and DosT
11.30 - 12.00
Computational and modeling studies on truncated hemoglobins
12.00 - 12.15
Radical Intermediates of Anaerobic Iron Oxidation in WT Bacterioferritin and Variants
12.15 - 12.30
Nitrite and nitric oxide binding of GLB-33, a unique chimeric globin in Caenorhabditis elegans examined with EPR and UV-vis spectroscopy
12.30 - 14.30
Lunch
Poster session
14.30 - 17.45
Silvia Dewilde
Alessandra Pesce
Cristiano Viappiani
Alessandra Pesce
Cristiano Viappiani
Session 4: Vertebrate Oxygen Binding Proteins
14.30 - 15.00
Roles of nitrite and cytoglobin 1 during zebrafish heart regeneration
15.00 - 15.30
Investigating the structural dynamics of heme proteins with TR-WAXS
15.30 - 16.00
Cytoglobin-1 in the Antarctic fish: From the function to the structural properties.
16.00 - 16.30
Coffee - break
16.30 - 17.00
Neuroglobin and cytoglobin: Lessons from knockout models and single-cell expression data
17.00 - 17.30
Free energy barriers for distal His binding and dissociation in hexacoordinated hemoglobins: A case of entropy-enthalpy compensation
17.30 - 17.45
Structural Insight into the Double Allosteric Mechanism for the Oxygenation Function in Hemoglobin: Beyond the MWC Model
20.00
Dinner
9.00 - 12.45
Thorsten Burmester
Jay F. Storz
Cinzia Verde
Jay F. Storz
Cinzia Verde
Session 5: Evolution of Oxygen Binding Proteins
9.00 - 9.30
Evolution of vertebrate hemoglobin loci and their regulatory elements
9.30 - 10.00
Evolution and diversity of hemerythrin across Metazoa
10.00 - 10.30
Evolution and functional diversification of globins in lungfish
10.30 - 11.00
Coffee - break
11:00 – 11:15
Diversity and evolution of extracellular hemoglobins in Metazoa
11.15 - 11.45
Resurrected respiratory proteins reveal molecular mechanisms behind convergent evolution of improved breath-hold diving capacity in the extinct penguin-like great auk Pinguinis imprennis
11.45 - 12.15
Ancestral protein resurrection reveals mutational pathways and functional mechanisms of hemoglobin adaptation
12.15 - 12.45
Towards an integrated view of the evolution of animal globins: The arthropod case.
12.45 - 14.30
Lunch
Poster session
14.30 - 18.00
Angela Fago
John Olson
Robert K. Poole
John Olson
Robert K. Poole
Session 6: Interactions with Reactive Oxygen, Nitrogen, and Sulfur Species
14.30 - 15.00
H-NOX and NosP: Nitric oxide-responsive hemoproteins that regulate bacterial biofilms
15.00 - 15.30
The cytochrome bd-I respiratory oxidase sensitises multidrug-resistant E. coli to antibiotics during nitric oxide exposure
15.30 - 16.00
Hydrogen sulfide and hemeproteins: Transportation, activation, turnover, and inactivity
16.00 - 16.30
Coffee - break
16.30 - 17.00
Development of a neuroglobin-based antidote for carbon monoxide poisoning
17.00 - 17.30
Endothelial cell a-globin and its molecular chaperone a-hemoglobin–stabilizing protein regulate arteriolar contractility
17.30 - 17.45
Heme Iron as Target for Inorganic Sulfide
17.45 - 18.00
A novel physiological role of ferric hemoglobin in H2S transport?
18.00
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